An Expanded Overview

What You Need to Know About the Disease of Addiction

The pronoun ‘he’ is used in the following text for ease of reading. It is a scientific fact that addiction affects both males and females equally.

Since 1956, addiction/alcoholism has been considered a primary disease by the American Medical Association. It has only been recently, however, that research has discovered the etiology of the disease of addiction. Through animal studies as well as imaging studies of humans, scientists have concluded that addiction is a disease of the brain. The part of the brain that malfunctions is the mesolimbic dopamine system, the seat of reward system that reacts to pain and pleasure. More specifically, the neurotransmission system is hijacked by drugs. At some point in the addict’s using life a metaphorical switch is thrown that causes the flooding or depletion of neurochemicals, foremost of which is dopamine. At this point the addict has lost all voluntary control of their consumption and uses drugs simply to feel “normal”. The biological need for drugs leads, inevitably, to damage the rest of the addict’s life.

The Early, Adaptive Stage of Alcoholism

One of the first symptoms of addiction is, ironically and tragically, an ability to increase drugs intake and still function “normally.” It is ironic because most diseases incur immediate and obvious penalties, not benefits, and result in reduced functioning rather than improvement in functioning. But in the early stages of addiction, the addict is not sick, in pain, or visibly abnormal. In fact, the early, adaptive stage of addiction appears to be marked by the opposite of disease, for the addict is “blessed” with a supernormal ability to tolerate drugs and enjoy their euphoric and stimulating effects. This improvement in functioning is tragic because the addict has little or no warning of the deterioration inevitably to follow.

In the early stage, the disease is subtle and difficult to recognize. It is characterized by adaptations in the liver and central nervous system, increased tolerance to drugs, and improved performance when using.

“The early stage of alcoholism is characterized by Adaptation, Tolerance, and Improved Performance”

A general biological rule holds that when any bodily system is under stress it either adapts of suffers damage. Adaptation is actually a tool of survival, helping the body endure stressful changes in internal or external environments. Adaptational responses occur rapidly, spontaneously, and in most cases, without the person’s conscious knowledge.

The adaptations which occur in the early stage of addiction are of two kinds: those affecting the metabolism of the drug, and those taking place in the central nervous system and contributing to addiction. Both types of adaptation have direct effects on the addict’s ability to use large amounts of drugs without becoming noticeably effected (tolerance) and actually to function better when he is using than when he is not using (improved performance).


Every user has a specific tolerance to drugs. Below his tolerance level, the user can function more or less normally; at levels above his tolerance threshold, he will act high. Tolerance is therefore a condition that can only be measured accurately in a laboratory where the user’s blood level and behavior can be carefully monitored.

Addicts typically experience a dramatic climb in tolerance in the first stage of addiction and can often use huge amounts of drugs without showing obvious impairment of their ability to walk, talk, think, and react. Anyone who observes the early- and middle-stage addict’s using behavior is familiar with the fact that the typical addict can use as much as an ounce of marijuana, several lines of cocaine, a liter of wine, a dozen beers, or even a bottle of whisky without acting high or drunk.

Improved Performance

In this early, hidden stage of addiction, the only visible difference between the addict and the non-addict is improved performance in the addict when he uses and deterioration in performance when he stops using.

Addicts in the early, adaptive stage of their disease also show improvement of functioning as the blood drug level begins to rise. But unlike in the non-addict, this improvement continues with additional using. Even when drug levels remain fairly high—levels which would overwhelm the non-addict, causing him to stumble, stutter, and sway—the early addict is often able to talk coherently, walk a straight line, or skillfully maneuver a car. Only when the addict stops using and his blood drug level (BDL) descends, does his performance deteriorate—and it does so very rapidly.

Tragically, the addict can only temporarily control his using behavior. Over a period of time (weeks or years, depending on the drug), the cells’ dependence becomes more firmly entrenched until, at some point, the addict no longer has a choice. He needs drugs to function, and he suffers terribly when he stops using them. The benefits of adaptation are gradually overshadowed by the penalties of deterioration.

The Middle Stage of Alcoholism

As physiological changes gradually occur, the penalties of using begin to outweigh the benefits. Pleasurable using for a “high,” a lift in feeling and performance from a relatively normal base, gives way to a more urgent “using for medicine” to “cure” the pain and misery caused by previous using. The basic cause of the increase in penalties is deterioration. Organs and systems that once welcomed the large doses of drugs and tolerated its toxic aftereffects are being damaged. Now when the addict stops using, his suffering is more severe and prolonged.

Talk to someone who understands
The middle stage of addiction is characterized by Physical Dependence, Craving and Loss of Control
Physical Dependence

As the addict uses more, and more often, to get the desired effect, the cells of his body are soaked in drugs for long periods of time. The cell membranes become increasingly resistant to drugs’s effects, and the mitochondria within the cells increase in size and shift functions in order to accommodate the drugs. With these changes, the adapted cells are able to live and thrive in an environment where drugs are continually present in large amounts.

If the addict over-uses his tolerance, the cells will be overwhelmed, and he will get drunk or high. If he stops using, the addicted cells will suddenly be thrown into a state of acute distress. They have become unable to function normally without drugs. The cells’ distress when drugs are no longer present in the body, or when the BDL is falling, is evident in various symptoms known as “the withdrawal syndrome.” Withdrawal symptoms demonstrate that physical dependence exists; they are the visible signs of addiction.


Craving is the overwhelming need for use. Like everything else in addiction, craving is progressive. In the middle stages of the disease, craving becomes a need—the addict needs to use because his cells are physically dependent on drugs. As tolerance increases and physical dependence sets in, the addict gradually loses psychological control over his physiological need for drugs. Will power, self-restraint, and the ability to say “no” have no power over addict craving. The physical need for drugs overshadows everything else in the addict’s life.

Loss of Control

As the addict progressively loses control over his using, he is no longer able to restrict it to socially and culturally accepted times and places. He often uses more than he intended, and the using continues despite extremely punishing consequences. He may use in the morning, at lunch, in the middle of the night; he may use in the car, the bathroom, the garage, or the closet as well as the tavern. His using behavior can no longer be disguised as normal or even heavy using. His inability to stop using—despite his firm resolution that he will stop—is striking confirmation that he is physically addicted to drugs.

The addict loses control over his using because his tolerance decreases and the withdrawal symptoms increase. The addict’s tolerance, which was so high in the early stages of the disease, begins to decrease because his cells have been damaged and can no longer tolerate large amounts of drugs. While tolerance in lessening, the withdrawal symptoms are increasing in severity. The addict is now in the dangerous position of needing to use because he suffers terribly when he stops using but being unable to handle the high levels of drugs needed to relieve the symptoms. He has also lost the ability to judge accurately how much drugs his body can handle. As a result, he often over-medicates himself with drugs, using to the point where he either loses consciousness or becomes so violently ill that he is forced to stop using.

The Late, Deteriorative Stage of Addiction

The late-stage addict spends most of his time using, since otherwise his agony is excruciating. During the late stages of addiction, the addict’s mental and physical health are seriously deteriorated. Damage to vital organs saps the addict’s physical strength; resistance to disease and infection is lowered; mental stability is shaken and precarious. The late-stage addict is so ravaged by his disease that he cannot even understand that drugs are destroying him. He is only aware that drugs offer quick and miraculous relief from the constant agony, mental confusion, and emotional turmoil. Drugs, his deadly poison, are also his necessary medicine.

“The late, deteriorative stage of addiction is characterized by Malnutrition, Secondary Disease, and Death”

All addicts suffer from malnutrition to some degree. A number of factors work together to make this condition almost synonymous with addiction. Large amounts of drugs interfere with digestion and passage of nutrients from the intestines into the bloodstream. The addict’s liver has a decreased ability to convert and release nutrients and make them available throughout the body. Without adequate nutrients, the cells, already weakened by long exposure to drugs’ toxic effects, are not able to create bone, tissue, blood, or energy. The sick and injured cells thus do not have the resources to repair themselves, and damage continues unchecked.

Even the addict’s earliest psychological and social problems stem from or are aggravated by nutritional deficiencies. For example, a thiamine deficiency (extremely common in addicts) can cause loss of mental alertness, easy fatigue, loss of appetite, irritability, and emotional instability. If the deficiency is allowed to continue, more severe mental confusion and loss of memory may develop.

In the later stages of addiction, the addict is often so sick that he cannot eat, thus aggravating the already serious nutritional deficiencies. Massive vitamin or mineral deficiencies caused by long and heavy use may result in several unusual diseases of the central nervous system, including polyneuropathy (tingling sensations), Wernicke’s encephalopathy (headaches, tingling, double vision), Korsakoff’s psychosis (hallucinations), and amblyopia (blurred vision).

Secondary Diseases scientifically linked with late-stage addiction

Heart Failure is characterized by symptoms of cardiomyopathy (disease of the heart muscle), cardiac arrhythmia (abnormal variations of heart beat), and hypertension (high blood pressure).


Fatty Liver is characterized by enlarged, inflamed fatty deposits. Symptoms include nausea, jaundice, and loss of appetite.


Hepatitis, or addict hepatitis, is characterized by a liver which becomes inflamed, swollen, and extremely tender.


Cirrhosis is characterized by a liver which is virtually plugged with scar tissue and which can no longer remove poisons and toxins from the body’s blood supply.

Gastrointestinal Disorders

Gastritis is an inflammation of the stomach lining severe enough to cause bleeding, bloating, indigestion, nausea, and headache.


Ulcers form in response to increased secretions of hydrochloric acid in late-stage addicts.

Respiratory Tract Diseases

In general, addiction causes damage to the lungs by interfering with the body’s normal defense mechanisms and thereby making the addict susceptible to respiratory infection and injury. This interference with normal functioning can lead to:

  • Tuberculosis
  • Chronic Bronchitis
  • Emphysema
  • Lung Abscess
  • Pneumonia

In addition, addicts appear to have an increased risk of head and neck, esophageal, lung, and liver cancers. In each of these cancers, drugs probably acts in a different way, sometimes directly affecting the cells, other times indirectly increasing the cells’ susceptibility to cancer. Late-stage addicts also exhibit a higher risk for pancreatitis, an inflamed gland condition characterized by severe pain in the upper abdomen, nausea, vomiting, and constipation.


If the addict continues to use, drugs will kill him one way or another. Estimates vary, but according to one source, one-third of addicts’ deaths are from suicides or accidents such as drownings, fires from passing out with a lighted cigarette, head injuries from falling, accidental poisoning, or car crashes. Those who survive these hazards are destroyed by direct and massive damage to body organs and systems.

Causes of Death in a Group of Addicts include: cardiovascular disease (30%), cirrhosis (24%), upper gastrointestinal & lung cancer (15%), addiction (14%), pneumonia (7%), and other causes (14%).—from W. Schmidt and R.E. Popham, unpublished data, “Deaths in 1823 Male Addicts, Corrected for the Expected Mortality in Each Subgroup” (1978).

Stages of Recovery
Early Recovery

Recovery can take up to two years to become firmly established. Early recovery spans the first six months for most patients, and is the time when the risk of relapse is the highest. This is the time the patient is struggling with the major adjustments he must make. He begins to deal with the environmental and social cues to use or use again, he develops new ways of dealing with stress at work and in personal relationships, he learns to deal with the mood swings and depression common in early recovery, he must begin the process of building a sober support system through attendance in AA or other support groups, and he starts developing sober social circles and activities.

Middle Stage Recovery

This occurs during the second six months of sobriety. During this time the patient must learn to deal with the physical, social, and psychological adjustments of sobriety. New relationships must be forged with loved ones because the behaviors of the past have changed so in recovery. The patient commonly goes through a grieving process, both over losses that occurred during drug use, and also over the loss of their “old life” and old friends. Reestablishing the ability to experience emotion is important, because addiction causes abnormal responses to loss. Part of recovery is learning to deal with past, unresolved loss.

Late Stage Recovery

The third stage of recovery begins after one year. By this time the patient has gone through the adjustment process of early- and middle-stage recovery. He has gained confidence that the support systems and tools learned in treatment and recovery work. This is a time of stability and of becoming comfortable with recovery. However, abstinence alone does not necessarily mean a successful recovery is under way. There is a difference between being “Dry” (abstinent) and “Sober” (in successful recovery).

The “Dry” patient is not presently using alcohol or drugs, however he has not changed his past using lifestyle, nor come to comfortable terms with the need for permanent sobriety. He is ambivalent about life, where the “Sober” person looks forward to his new life of sobriety. The “Dry” patient feels abstinence as a constant sacrifice, and frequently thinks about using. The “Sober” patient sees abstinence as a gift to himself. The “Dry” patient continues the self-centered ways of his past, maintaining the old behaviors, friends, and activities. He doesn’t take care of himself physically or psychologically, and continues to suffer from guilt and shame because he has not come to terms with his past or present life. Patients who are merely “Dry” have a much higher risk of relapse than those “Sober” patients who have made major life changes necessary for successful long-term recovery.

Contact us today at Lakeside-Milam Recovery Centers for a FREE addiction evaluation.
Local: (425) 823-3116 or toll free: (800) 231-4303 or email us confidentially